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AFPep

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AFPep (Alpha Fetoprotein Peptide) is an orally active cyclic peptide with molecular weight of 969 Daltons and is derived from the anti-oncogenic active site (residues 472-479) of alpha fetoprotein (AFP). Using the standard amino acid abbreviations, AFPep has the sequence cyclo-(EKTOVNOGN), where O is hydroxyproline. This peptide has been shown in experimental animal models to be efficacious in the... Read enhanced Wikipedia article

Factz from Wikipedia: we found the following about AFPep help

inhibited :
proliferation, growth and phosphorylation.

Results for "AFPep inhibited proliferation"

AFPep Anti cancer effects: AFPep inhibits the proliferation of estrogen receptor-positive human breast cancer cells growing in culture (1).

AFPep In culture, AFPep inhibits the estrogen induced proliferation of T47D cells but has no effect on the basal growth (4).

Results for "AFPep inhibited growth"

AFPep Anti estrogenic effects: AFPep inhibits estrogen-stimulated growth of immature mouse uterus and thus is antiestrogenic (3).

Results for "AFPep inhibited phosphorylation"

AFPep AFPep also inhibits phosphorylation of the estrogen receptor and activates the phosphorylation of p53 (4).

increased :
efficacy and effects.

Results for "AFPep increased efficacy"

AFPep AFPep increases the efficacy and decreases the toxicities of Tamoxifen

Results for "AFPep increased effects"

AFPep It has been established that AFPep when used in combination with tamoxifen, reduces the uterine hyperplasia and increases the antitumour effects of tamoxifen (5).

decreased  
toxicities.

Results for "AFPep decreased toxicities"

AFPep AFPep increases the efficacy and decreases the toxicities of Tamoxifen

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    AFPep

    AFPep is a cyclic nonapeptide with molecular weight 969 D and is derived from the antioncogenic active site of alpha fetoprotein (AFP). Using the standard amino acid abbreviations, AFPep has the sequence cyclo(EKTOVNOGN), where O is hydroxyproline.
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    Alpha-fetoprotein

    Many functions have been proposed for AFP; an anti-cancer active site peptide has been identified and is referred to as AFPep.

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