Finding:

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   Imatinib

   Imatinib is a drug used to treat certain types of cancer. ... Severe congestive cardiac failure is an uncommon but recognised side effect of imatinib and mice treated with large doses of imatinib show toxic damage to their myocardium.
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   Cancer

   Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. ... Prominent examples are the tyrosine kinase inhibitors imatinib and gefitinib.
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   Sunitinib

   Sunitinib (marketed as Sutent, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. ... "Phase II study of SU11248, a multi-targeted tyrosine kinase inhibitor in patients with previously treated metastatic breast cancer".
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   History of cancer chemotherapy

   Although this effect lasted only a few weeks, this was the first step to the realization that cancer could be treated by pharmacological agents (Goodman et al 1946). ... Imatinib precisely inhibits this kinase.
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   Immunohistochemistry

   In both cases, the tissue is treated to rupture the membranes, usually by using a kind of detergent such as Triton X-100. ... Imatinib, an intracellualar tyrosine kinase inhibitor, was developed to treat chronic myelogenous leukemia, a disease characterized by the formation of a specific abnormal tyrosine kinase.
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   Chronic myelogenous leukemia

   Chronic phase CML is treated with inhibitors of tyrosine kinase, the first of which was imatinib mesylate (marketed as Gleevec or Glivec; previously known as STI-571). ... Types of cancer
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   Somatic evolution in cancer

   ↑ Roche-Lestienne C, Preudhomme C: Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment. ... ↑ Taplin ME, Bubley GJ, Ko YJ, Small EJ, Upton M, Rajeshkumar B, Balk SP: Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.
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   Chemotherapy

   Most cancers are now treated in this way. ... These include monoclonal antibodies and the new tyrosine kinase inhibitors e.g. imatinib mesylate (Gleevec or Glivec), which directly targets a molecular abnormality in certain types of cancer (chronic myelogenous leukemia, gastrointestinal stromal tumors).
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   Cancer immunotherapy

   Experts say that this case could mark a landmark in the treatment of cancer in general. ... Axitinib · Bosutinib · Cediranib · Dasatinib · Erlotinib · Gefitinib · Imatinib · Lapatinib · Lestaurtinib · Nilotinib · Semaxanib · Sorafenib · Sunitinib · Vandetanib
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    Leukemia

    Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. ... Treatment is with imatinib (Gleevec) or other drugs.

Explore the following pages on Powerset:

• Imatinib,
• Cancer,
• Sunitinib,
• History of cancer chemotherapy,
• Immunohistochemistry,
• Chronic myelogenous leukemia,
• Somatic evolution in cancer,
• Chemotherapy,
• Cancer immunotherapy,
• Leukemia